Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation

Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation

Blog Article

Abstract The marsupial specific RSX lncRNA is Digging the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation.We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica), identifying 135 proteins, of which 54 had orthologues in the Structural Heatsinks XIST interactome.Both interactomes were enriched for biological pathways related to RNA processing, regulation of translation, and epigenetic transcriptional silencing.

This represents a remarkable example showcasing the functional coherence of independently evolved lncRNAs in distantly related mammalian lineages.